Functional foods, mucosal immunity and aging: effect of probiotics on intestinal immunity in young and old rats
نویسندگان
چکیده
The elderly are characterized by immunosenescence which is accompanied by an increase in the incidence of infectious diseases, especially in the intestinal tract. There is evidence suggesting that certain probiotic organisms have immunomodulatory properties. Therefore, the effects of feeding fermented milk products on the intestinal mucosal immune response was examined in young and senescent rats. Serum anticholera toxin (CTx) immunoglobulin A (IgA) antibody titers were significantly higher in kefir-fed young rats in comparison to young control-fed (no kefir) animals. This increase was accompanied by enhanced in vitro IgA antibody secretion by Peyer’s patch and intestinal lamina propria lymphocytes. No similar enhancements of serum or lymphocyte IgA antibody responses were observed in the kefir-fed versus control-fed old rats. The fact that kefir enhanced responses were observed only in the young rats suggests that probiotics may affect the intestinal immune response differentially in young and old animals.
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